An HIV-positive patient on ART develops immune reconstitution inflammatory syndrome (IRIS) manifesting as worsening lymphadenopathy and fever 3 weeks ...

Question

An HIV-positive patient on ART develops immune reconstitution inflammatory syndrome (IRIS) manifesting as worsening lymphadenopathy and fever 3 weeks after starting ART. His CD4 has risen from 40 to 120 cells/µL. What is the management of moderate paradoxical IRIS?

Accepted Answer

Continue ART and treat the underlying opportunistic infection; add NSAIDs or corticosteroids for moderate-to-severe IRIS symptoms

Answer

Stop ART permanently

Answer

Switch to a different ART regimen

Answer

Reduce the ART dose by 50%

Answer

No management is needed

uk-dtmh MCQ (SBA): IRIS Management

An HIV-positive patient on ART develops immune reconstitution inflammatory syndrome (IRIS) manifesting as worsening lymphadenopathy and fever 3 weeks after starting ART. His CD4 has risen from 40 to 120 cells/µL. What is the management of moderate paradoxical IRIS?