A 30-year-old man from Mozambique presents with a painless oral ulcer on his hard palate. He is HIV-positive with CD4 75 cells/µL. Biopsy shows intrac...

Question

A 30-year-old man from Mozambique presents with a painless oral ulcer on his hard palate. He is HIV-positive with CD4 75 cells/µL. Biopsy shows intracellular organisms consistent with Histoplasma capsulatum var. capsulatum. What is the first-line treatment for disseminated histoplasmosis in HIV?

Accepted Answer

Induction with IV liposomal amphotericin B (3 mg/kg/day for 2 weeks) followed by oral itraconazole maintenance for at least 12 months

Answer

Oral fluconazole for 2 weeks

Answer

Oral voriconazole for 6 weeks

Answer

IV caspofungin

Answer

Oral co-trimoxazole

uk-dtmh MCQ (SBA): Disseminated Histoplasmosis Treatment

A 30-year-old man from Mozambique presents with a painless oral ulcer on his hard palate. He is HIV-positive with CD4 75 cells/µL. Biopsy shows intracellular organisms consistent with Histoplasma capsulatum var. capsulatum. What is the first-line treatment for disseminated histoplasmosis in HIV?