A TB patient in South Africa develops hepatitis during treatment. After stopping all hepatotoxic drugs and waiting for LFTs to normalise, the sequenti...

Question

A TB patient in South Africa develops hepatitis during treatment. After stopping all hepatotoxic drugs and waiting for LFTs to normalise, the sequential reintroduction of drugs begins. Which drug is reintroduced first and why?

Accepted Answer

Rifampicin, as it is least likely to be the causative agent of hepatotoxicity and is the most important sterilising drug

Answer

Isoniazid, as it is the most important bactericidal drug

Answer

Pyrazinamide, as it must be restarted first

Answer

Ethambutol, as it is the safest

Answer

All three are reintroduced simultaneously

uk-dtmh MCQ (SBA): Sequential Drug Reintroduction After DILI

A TB patient in South Africa develops hepatitis during treatment. After stopping all hepatotoxic drugs and waiting for LFTs to normalise, the sequential reintroduction of drugs begins. Which drug is reintroduced first and why?