A 28-year-old man from Assam, India, is diagnosed with visceral leishmaniasis. He is HIV-negative. The national programme uses single-dose liposomal a...

Question

A 28-year-old man from Assam, India, is diagnosed with visceral leishmaniasis. He is HIV-negative. The national programme uses single-dose liposomal amphotericin B 10 mg/kg as first-line. What is the mechanism of action of amphotericin B against Leishmania?

Accepted Answer

Direct binding to ergosterol in the parasite cell membrane, creating pores that disrupt membrane integrity and cause leakage of intracellular contents

Answer

Inhibition of ergosterol synthesis in the parasite membrane

Answer

Inhibition of DNA synthesis

Answer

Inhibition of protein synthesis at the ribosomal level

Answer

Inhibition of folate metabolism

uk-dtmh MCQ (SBA): Amphotericin B Mechanism

A 28-year-old man from Assam, India, is diagnosed with visceral leishmaniasis. He is HIV-negative. The national programme uses single-dose liposomal amphotericin B 10 mg/kg as first-line. What is the mechanism of action of amphotericin B against Leishmania?