A 45-year-old man from Bangladesh presents with profuse rice-water stools. Stool culture confirms Vibrio cholerae O1 El Tor, serotype Inaba. What is t...

Question

A 45-year-old man from Bangladesh presents with profuse rice-water stools. Stool culture confirms Vibrio cholerae O1 El Tor, serotype Inaba. What is the virulence factor responsible for the profuse secretory diarrhoea?

Accepted Answer

Cholera toxin (CT) - an AB5 toxin that activates adenylate cyclase, increasing intracellular cAMP and causing massive chloride and water secretion into the intestinal lumen

Answer

Shiga toxin

Answer

Lipopolysaccharide endotoxin

Answer

Haemolysin

Answer

Capsular polysaccharide

uk-dtmh MCQ (SBA): Cholera Toxin Mechanism

A 45-year-old man from Bangladesh presents with profuse rice-water stools. Stool culture confirms Vibrio cholerae O1 El Tor, serotype Inaba. What is the virulence factor responsible for the profuse secretory diarrhoea?