A 30-year-old South African woman on first-line TLD (tenofovir/lamivudine/dolutegravir) for HIV has been fully suppressed (undetectable viral load) fo...

Question

A 30-year-old South African woman on first-line TLD (tenofovir/lamivudine/dolutegravir) for HIV has been fully suppressed (undetectable viral load) for 2 years. She now wishes to become pregnant. What is the current WHO position on dolutegravir use in women of childbearing potential and during pregnancy?

Accepted Answer

WHO recommends DTG-based regimens for all people living with HIV, including women of childbearing potential and pregnant women, based on updated safety data showing the benefits outweigh the small initial safety signal regarding neural tube defects

Answer

DTG must be stopped immediately if pregnancy is planned

Answer

DTG is absolutely contraindicated throughout pregnancy

Answer

DTG should be switched to efavirenz in the first trimester

Answer

DTG has no safety data in pregnancy

uk-dtmh MCQ (SBA): DTG in Pregnancy