A 30-year-old woman with sickle cell disease (HbSS) develops P. falciparum malaria in Nigeria. She presents with a haemoglobin of 4.5 g/dL, parasitaemia 3%, and acute chest syndrome. What is the most important consideration in managing her malaria?AStandard ACT is contraindicated in sickle cell diseaseBShe is at high risk of severe disease as homozygous sickle cell disease (HbSS) does NOT confer protection against malaria, unlike sickle cell trait (HbAS); aggressive treatment with IV artesunate and exchange transfusion may be neededCSickle cell disease provides complete immunity to malariaDChloroquine is the preferred treatment in sickle cell patientsEMalaria does not cause acute chest syndrome in sickle cell patientsCheck my answer