A 45-year-old man from Eritrea is being treated for smear-positive pulmonary TB. He is an HBV carrier (HBsAg positive). Which component of standard RI...

Question

A 45-year-old man from Eritrea is being treated for smear-positive pulmonary TB. He is an HBV carrier (HBsAg positive). Which component of standard RIPE therapy requires particular monitoring in this patient?

Accepted Answer

Isoniazid, rifampicin, and pyrazinamide - all three are potentially hepatotoxic and carry increased risk of drug-induced liver injury in chronic HBV carriers

Answer

Ethambutol - increased risk of optic neuritis with HBV

Answer

Streptomycin - increased nephrotoxicity with HBV

Answer

No additional monitoring is required

Answer

Only pyrazinamide requires monitoring

uk-dtmh MCQ (SBA): TB Treatment in HBV Carrier

A 45-year-old man from Eritrea is being treated for smear-positive pulmonary TB. He is an HBV carrier (HBsAg positive). Which component of standard RIPE therapy requires particular monitoring in this patient?