What is the WHO-recommended approach when a patient on first-line DTG-based ART has a confirmed virological failure (viral load 1000 copies/mL on two...

Question

What is the WHO-recommended approach when a patient on first-line DTG-based ART has a confirmed virological failure (viral load >1000 copies/mL on two consecutive measurements)?

Accepted Answer

Switch to a second-line regimen, typically a boosted protease inhibitor (e.g., atazanavir/ritonavir or darunavir/ritonavir) with two NRTIs

Answer

Continue the same regimen and enhance adherence counselling indefinitely

Answer

Stop ART entirely and retest in 6 months

Answer

Add a fourth drug to the current regimen

Answer

Switch to an NNRTI-based regimen

uk-dtmh MCQ (SBA): Second-line ART

What is the WHO-recommended approach when a patient on first-line DTG-based ART has a confirmed virological failure (viral load >1000 copies/mL on two consecutive measurements)?