A 28-year-old woman in Zambia with HIV and a CD4 count of 190 cells/µL is diagnosed with smear-positive pulmonary TB. She is to start standard RIPE an...

Question

A 28-year-old woman in Zambia with HIV and a CD4 count of 190 cells/µL is diagnosed with smear-positive pulmonary TB. She is to start standard RIPE anti-TB therapy. She is on DTG-based ART (TLD). What dose adjustment of dolutegravir is required when co-administered with rifampicin?

Accepted Answer

Dolutegravir dose must be increased from 50 mg once daily to 50 mg twice daily during rifampicin co-administration

Answer

No dose adjustment is required

Answer

Dolutegravir must be switched to efavirenz

Answer

Rifampicin must be replaced with rifabutin

Answer

Both drugs are contraindicated together

uk-dtmh MCQ (SBA): DTG-Rifampicin Interaction

A 28-year-old woman in Zambia with HIV and a CD4 count of 190 cells/µL is diagnosed with smear-positive pulmonary TB. She is to start standard RIPE anti-TB therapy. She is on DTG-based ART (TLD). What dose adjustment of dolutegravir is required when co-administered with rifampicin?