Hyperreactive malarial splenomegaly (HMS, formerly tropical splenomegaly syndrome) presents with massive splenomegaly, elevated IgM, and high malaria ...

Question

Hyperreactive malarial splenomegaly (HMS, formerly tropical splenomegaly syndrome) presents with massive splenomegaly, elevated IgM, and high malaria antibody titres in residents of malaria-endemic areas. What is the recommended treatment?

Accepted Answer

Prolonged antimalarial prophylaxis (e.g., proguanil or mefloquine) for months to years

Answer

Splenectomy

Answer

Praziquantel

Answer

No treatment required

Answer

Immunosuppressive therapy with prednisolone

uk-dtmh MCQ (SBA): Hyperreactive Malarial Splenomegaly

Hyperreactive malarial splenomegaly (HMS, formerly tropical splenomegaly syndrome) presents with massive splenomegaly, elevated IgM, and high malaria antibody titres in residents of malaria-endemic areas. What is the recommended treatment?