A 38-year-old man presents with P. falciparum malaria (parasitaemia 1.5%) and is treated with artemether/lumefantrine. He is also taking efavirenz-bas...

Question

A 38-year-old man presents with P. falciparum malaria (parasitaemia 1.5%) and is treated with artemether/lumefantrine. He is also taking efavirenz-based ART for HIV. What important drug interaction should be considered?

Accepted Answer

Efavirenz induces CYP3A4, reducing lumefantrine plasma concentrations and potentially decreasing antimalarial efficacy

Answer

Efavirenz increases lumefantrine levels, causing toxicity

Answer

There is no significant interaction between efavirenz and artemether/lumefantrine

Answer

Lumefantrine inhibits efavirenz metabolism, causing HIV drug resistance

Answer

Artemether inhibits reverse transcriptase, enhancing ART efficacy

uk-dtmh MCQ (SBA): Efavirenz-Lumefantrine Drug Interaction

A 38-year-old man presents with P. falciparum malaria (parasitaemia 1.5%) and is treated with artemether/lumefantrine. He is also taking efavirenz-based ART for HIV. What important drug interaction should be considered?