A 62-year-old man with chronic P. malariae infection presents with nephrotic syndrome. Renal biopsy shows thickening of the glomerular basement membra...

Question

A 62-year-old man with chronic P. malariae infection presents with nephrotic syndrome. Renal biopsy shows thickening of the glomerular basement membrane with subendothelial and mesangial deposits. Despite antimalarial treatment and complete parasite clearance, his proteinuria persists. Why does the nephropathy fail to resolve?

Accepted Answer

Because the immune-complex deposition has caused irreversible structural glomerular damage

Answer

Because P. malariae cannot actually be eradicated from the host

Answer

Because he has concurrent diabetic nephropathy

Answer

Because antimalarials are nephrotoxic and worsen the condition

Answer

Because renal function always improves within 12 months

uk-dtmh MCQ (SBA): Irreversibility of Quartan Nephropathy