A 37-year-old woman takes mefloquine prophylaxis for travel to West Africa. After the second dose she develops vivid nightmares, anxiety, and dizzines...

Question

A 37-year-old woman takes mefloquine prophylaxis for travel to West Africa. After the second dose she develops vivid nightmares, anxiety, and dizziness. She has no psychiatric history. What is the most appropriate management?

Accepted Answer

Switch to an alternative prophylactic agent such as atovaquone/proguanil or doxycycline

Answer

Continue mefloquine at the same dose as side effects are transient

Answer

Halve the mefloquine dose

Answer

Add a benzodiazepine to manage neuropsychiatric symptoms

Answer

Stop all prophylaxis as neuropsychiatric side effects indicate mefloquine allergy

uk-dtmh MCQ (SBA): Mefloquine Neuropsychiatric Side Effects

A 37-year-old woman takes mefloquine prophylaxis for travel to West Africa. After the second dose she develops vivid nightmares, anxiety, and dizziness. She has no psychiatric history. What is the most appropriate management?