Which of the following is the mechanism of action of atovaquone, the partner drug in the atovaquone/proguanil (Malarone) combination?...

Question

Which of the following is the mechanism of action of atovaquone, the partner drug in the atovaquone/proguanil (Malarone) combination?

Accepted Answer

Inhibition of the mitochondrial cytochrome bc1 complex (complex III) of the parasite electron transport chain

Answer

Inhibition of haem polymerisation in the parasite food vacuole

Answer

Inhibition of dihydrofolate reductase

Answer

Generation of free radicals via interaction with haem

Answer

Inhibition of the parasite's apicoplast fatty acid synthesis

uk-dtmh MCQ (SBA): Atovaquone Mechanism of Action