A 29-year-old man develops P. vivax malaria after travelling in Eritrea. He is treated with chloroquine. G6PD testing by fluorescent spot test shows i...

Question

A 29-year-old man develops P. vivax malaria after travelling in Eritrea. He is treated with chloroquine. G6PD testing by fluorescent spot test shows intermediate enzyme activity. What is the significance of intermediate G6PD activity for primaquine radical cure?

Accepted Answer

Intermediate activity indicates heterozygous female status, which still carries a risk of primaquine-induced haemolysis and requires modified dosing or close monitoring

Answer

Intermediate activity is equivalent to normal and primaquine can be given at standard dose

Answer

Intermediate activity contraindicates primaquine permanently

Answer

Intermediate activity is only found in males

Answer

Intermediate activity is a laboratory artefact and should be repeated in 6 months

uk-dtmh MCQ (SBA): G6PD Intermediate Activity and Primaquine

A 29-year-old man develops P. vivax malaria after travelling in Eritrea. He is treated with chloroquine. G6PD testing by fluorescent spot test shows intermediate enzyme activity. What is the significance of intermediate G6PD activity for primaquine radical cure?