A patient on multibacillary MDT for leprosy develops sudden onset of painful, tender erythematous nodules on the face, arms, and trunk. He also has fe...

Question

A patient on multibacillary MDT for leprosy develops sudden onset of painful, tender erythematous nodules on the face, arms, and trunk. He also has fever, arthralgia, and iridocyclitis. What is this reaction, and what is the first-line treatment?

Accepted Answer

Type 2 reaction (erythema nodosum leprosum); oral thalidomide or prednisolone

Answer

Type 1 (reversal) reaction; oral prednisolone

Answer

Lucio phenomenon; plasma exchange

Answer

Drug hypersensitivity reaction; stop all MDT drugs

Answer

Secondary bacterial skin infection; oral flucloxacillin

uk-dtmh MCQ (SBA): Erythema Nodosum Leprosum

A patient on multibacillary MDT for leprosy develops sudden onset of painful, tender erythematous nodules on the face, arms, and trunk. He also has fever, arthralgia, and iridocyclitis. What is this reaction, and what is the first-line treatment?