A 33-year-old man from rural Tanzania presents with massive enlargement of his left leg (elephantiasis). He also has chyluria. What is the pathophysio...

Question

A 33-year-old man from rural Tanzania presents with massive enlargement of his left leg (elephantiasis). He also has chyluria. What is the pathophysiological mechanism of lymphoedema in lymphatic filariasis?

Accepted Answer

Obstruction of lymphatic drainage by adult worms and secondary inflammatory fibrosis

Answer

Direct tissue invasion by microfilariae

Answer

Allergic reaction to mosquito saliva

Answer

Venous thrombosis caused by circulating antigens

Answer

Autoimmune vasculitis triggered by filarial antigens

uk-dtmh MCQ (SBA): Lymphatic Filariasis Pathophysiology

A 33-year-old man from rural Tanzania presents with massive enlargement of his left leg (elephantiasis). He also has chyluria. What is the pathophysiological mechanism of lymphoedema in lymphatic filariasis?