A 30-year-old HIV-positive man with a CD4 count of 55 cells/µL presents with ring-enhancing brain lesions on contrast CT. He has fever, headache, and ...

Question

A 30-year-old HIV-positive man with a CD4 count of 55 cells/µL presents with ring-enhancing brain lesions on contrast CT. He has fever, headache, and focal neurological signs. Toxoplasma IgG serology is positive. What is the most appropriate initial management?

Accepted Answer

Empirical treatment with sulfadiazine, pyrimethamine, and folinic acid

Answer

Brain biopsy

Answer

High-dose fluconazole

Answer

Anti-TB treatment

Answer

Dexamethasone alone

uk-dtmh MCQ (SBA): Cerebral Toxoplasmosis

A 30-year-old HIV-positive man with a CD4 count of 55 cells/µL presents with ring-enhancing brain lesions on contrast CT. He has fever, headache, and focal neurological signs. Toxoplasma IgG serology is positive. What is the most appropriate initial management?