A 35-year-old man from Uganda presents with headache, fever, and confusion over 2 weeks. His CD4 count is 45 cells/µL. Lumbar puncture reveals a high ...

Question

A 35-year-old man from Uganda presents with headache, fever, and confusion over 2 weeks. His CD4 count is 45 cells/µL. Lumbar puncture reveals a high opening pressure (32 cmH₂O), CSF protein 0.8 g/L, glucose 1.8 mmol/L (serum glucose 5.5 mmol/L), and India ink stain shows encapsulated yeast forms. What is the recommended initial treatment?

Accepted Answer

Intravenous amphotericin B deoxycholate plus flucytosine for 1 week, followed by fluconazole

Answer

Fluconazole 1200 mg daily

Answer

Voriconazole for 6 weeks

Answer

Itraconazole for 12 weeks

Answer

Caspofungin for 2 weeks

uk-dtmh MCQ (SBA): Cryptococcal Meningitis