A healthcare worker in the UK undergoes screening for latent tuberculosis infection (LTBI). Her interferon-gamma release assay (IGRA) is positive. She...

Question

A healthcare worker in the UK undergoes screening for latent tuberculosis infection (LTBI). Her interferon-gamma release assay (IGRA) is positive. She has no symptoms, normal chest X-ray, and has never been treated for TB. She is HIV-negative. What is the recommended treatment for LTBI according to NICE guidelines?

Accepted Answer

Isoniazid plus rifampicin for 3 months

Answer

Rifampicin monotherapy for 4 months

Answer

Standard RIPE for 2 months followed by isoniazid and rifampicin for 4 months

Answer

Isoniazid monotherapy for 6 months

Answer

No treatment required; annual IGRA monitoring

uk-dtmh MCQ (SBA): Latent TB Infection