A 60-year-old man is treated with intravenous artesunate for severe P. falciparum malaria. On day 14 post-treatment, routine blood tests show haemoglo...

Question

A 60-year-old man is treated with intravenous artesunate for severe P. falciparum malaria. On day 14 post-treatment, routine blood tests show haemoglobin has dropped from 10.2 g/dL to 7.1 g/dL despite clearance of parasitaemia. Direct antiglobulin test (DAT) is positive. Reticulocyte count is elevated. What is the most likely explanation?

Accepted Answer

Post-artesunate delayed haemolysis

Answer

Recrudescent malaria with sequestered parasites

Answer

Glucose-6-phosphate dehydrogenase deficiency triggered by primaquine

Answer

Splenic sequestration crisis

Answer

Disseminated intravascular coagulation

uk-dtmh MCQ (SBA): Post-artesunate Delayed Haemolysis