A 52-year-old postmenopausal woman on continuous combined HRT attends the GP asking about the difference between transdermal patches and oral tablets ...

Question

A 52-year-old postmenopausal woman on continuous combined HRT attends the GP asking about the difference between transdermal patches and oral tablets for oestrogen. She has a BMI of 28 kg/m² and no other risk factors. Which is the most clinically relevant advantage of transdermal oestrogen over oral?

Accepted Answer

Transdermal oestrogen bypasses first-pass hepatic metabolism, resulting in a lower risk of VTE and stroke compared with oral oestrogen

Answer

Transdermal oestrogen is more effective at controlling vasomotor symptoms

Answer

Transdermal oestrogen is cheaper

Answer

Transdermal oestrogen can be applied to the breasts for local effect

Answer

There is no difference between routes

uk-drcog MCQ (SBA): Transdermal vs Oral Oestrogen - VTE Advantage