A 33-year-old woman at 10 weeks of gestation presents to the GP with severe nausea. She has tried cyclizine without adequate relief. The GP considers ...

Question

A 33-year-old woman at 10 weeks of gestation presents to the GP with severe nausea. She has tried cyclizine without adequate relief. The GP considers prescribing ondansetron. What is the single most important safety concern with ondansetron in the first trimester?

Accepted Answer

Ondansetron has been associated with a small increased risk of orofacial clefts (cleft palate) when used in the first trimester, based on epidemiological data

Answer

Ondansetron causes neural tube defects

Answer

Ondansetron is absolutely contraindicated in pregnancy

Answer

Ondansetron causes fetal cardiac defects

Answer

There are no safety concerns with ondansetron in pregnancy

uk-drcog MCQ (SBA): Ondansetron First-Trimester Cleft Risk

A 33-year-old woman at 10 weeks of gestation presents to the GP with severe nausea. She has tried cyclizine without adequate relief. The GP considers prescribing ondansetron. What is the single most important safety concern with ondansetron in the first trimester?