A 52-year-old woman presents to the GP with persistent bloating for 8 weeks. Her CA-125 is 42 U/mL (elevated). A pelvic ultrasound shows normal ovarie...

Question

A 52-year-old woman presents to the GP with persistent bloating for 8 weeks. Her CA-125 is 42 U/mL (elevated). A pelvic ultrasound shows normal ovaries with no masses. Despite normal ultrasound, she has persistent symptoms and an elevated CA-125. Which is the single most appropriate next step?

Accepted Answer

Refer on a suspected cancer pathway (2-week wait) as the CA-125 is ≥35 and symptoms persist, even though the ultrasound is normal

Answer

Reassure as the ultrasound is normal

Answer

Repeat the CA-125 in 6 months

Answer

Prescribe a proton pump inhibitor

Answer

Arrange a CT abdomen before referral

uk-drcog MCQ (SBA): Elevated CA-125 with Normal Ultrasound

A 52-year-old woman presents to the GP with persistent bloating for 8 weeks. Her CA-125 is 42 U/mL (elevated). A pelvic ultrasound shows normal ovaries with no masses. Despite normal ultrasound, she has persistent symptoms and an elevated CA-125. Which is the single most appropriate next step?