A 32-year-old woman at 16 weeks of gestation attends the GP with a confirmed deep vein thrombosis in her left calf. She is being treated with low-mole...

Question

A 32-year-old woman at 16 weeks of gestation attends the GP with a confirmed deep vein thrombosis in her left calf. She is being treated with low-molecular-weight heparin (LMWH). She asks whether she can take warfarin instead. Which is the most important reason warfarin is avoided in the first trimester?

Accepted Answer

Warfarin crosses the placenta and causes warfarin embryopathy (nasal hypoplasia and stippled epiphyses) when used in the first trimester

Answer

Warfarin causes neonatal haemorrhage only

Answer

Warfarin is less effective than LMWH

Answer

Warfarin interacts with folic acid

Answer

Warfarin is associated with gestational diabetes

uk-drcog MCQ (SBA): Warfarin Embryopathy