A 30-year-old woman with PCOS and anovulatory infertility is commenced on letrozole for ovulation induction by the fertility clinic. She asks the GP h...

Question

A 30-year-old woman with PCOS and anovulatory infertility is commenced on letrozole for ovulation induction by the fertility clinic. She asks the GP how letrozole works. Which is the most accurate explanation?

Accepted Answer

Letrozole is an aromatase inhibitor that reduces oestrogen levels, releasing the hypothalamic-pituitary axis from negative feedback and promoting FSH release to stimulate follicular development

Answer

Letrozole is a gonadotrophin that directly stimulates the ovary

Answer

Letrozole is a progesterone receptor modulator

Answer

Letrozole directly stimulates the endometrium

Answer

Letrozole suppresses LH to prevent premature ovulation

uk-drcog MCQ (SBA): Letrozole Mechanism of Action

A 30-year-old woman with PCOS and anovulatory infertility is commenced on letrozole for ovulation induction by the fertility clinic. She asks the GP how letrozole works. Which is the most accurate explanation?