A 33-year-old woman at 12 weeks of gestation presents to the GP having received a high-risk result (1 in 80) on her combined screening test for Down s...

Question

A 33-year-old woman at 12 weeks of gestation presents to the GP having received a high-risk result (1 in 80) on her combined screening test for Down syndrome. She is distressed and asks about further testing options. Which is the single most appropriate next step to offer?

Accepted Answer

Offer non-invasive prenatal testing (NIPT) as a further screening step, or diagnostic testing (CVS or amniocentesis)

Answer

Repeat the combined screening test in 2 weeks

Answer

Proceed directly to amniocentesis without discussing NIPT

Answer

Reassure that 1 in 80 still means an 80% chance the baby is unaffected

Answer

Offer a detailed anomaly scan at 20 weeks as a diagnostic test

uk-drcog MCQ (SBA): High-Risk Combined Test - NIPT Pathway

A 33-year-old woman at 12 weeks of gestation presents to the GP having received a high-risk result (1 in 80) on her combined screening test for Down syndrome. She is distressed and asks about further testing options. Which is the single most appropriate next step to offer?