A 24-year-old woman with well-controlled epilepsy on lamotrigine monotherapy and currently using a Cu-IUD asks whether she could switch to CHC. What s...

Question

A 24-year-old woman with well-controlled epilepsy on lamotrigine monotherapy and currently using a Cu-IUD asks whether she could switch to CHC. What should she be told about the specific interaction between CHC and lamotrigine?

Accepted Answer

CHC reduces lamotrigine levels (increasing seizure risk) and during the HFI, lamotrigine levels rise (risking toxicity). CHC with lamotrigine is UKMEC 3. The Cu-IUD is preferable

Answer

There is no interaction; she can switch freely

Answer

Lamotrigine reduces CHC efficacy

Answer

CHC increases lamotrigine levels

Answer

Only the combined patch interacts with lamotrigine

uk-dfsrh MCQ (SBA): Lamotrigine CHC UKMEC 3 Bidirectional Interaction

A 24-year-old woman with well-controlled epilepsy on lamotrigine monotherapy and currently using a Cu-IUD asks whether she could switch to CHC. What should she be told about the specific interaction between CHC and lamotrigine?