A woman using a combined oral contraceptive pill (COC) is started on lamotrigine for bipolar disorder. What specific drug interaction should she be co...

Question

A woman using a combined oral contraceptive pill (COC) is started on lamotrigine for bipolar disorder. What specific drug interaction should she be counselled about?

Accepted Answer

Lamotrigine increases oestrogen levels

Answer

Lamotrigine reduces COC efficacy

Answer

The COC increases lamotrigine clearance, reducing lamotrigine serum levels; and during the hormone-free interval, lamotrigine levels may rise, causing potential toxicity

Answer

There is no interaction

Answer

The COC reduces lamotrigine absorption

uk-dfsrh MCQ (SBA): Lamotrigine COC Bidirectional Interaction

A woman using a combined oral contraceptive pill (COC) is started on lamotrigine for bipolar disorder. What specific drug interaction should she be counselled about?