A 32-year-old woman with Graves’ disease has been on Carbimazole for 18 months. She presents with sore throat and fever. Her neutrophil count is 0.2 ×...

Question

A 32-year-old woman with Graves’ disease has been on Carbimazole for 18 months. She presents with sore throat and fever. Her neutrophil count is 0.2 × 10^9/L. What is the most appropriate next step in management?

Accepted Answer

Stop Carbimazole immediately and start broad-spectrum IV antibiotics

Answer

Continue Carbimazole and observe

Answer

Increase the Carbimazole dose

Answer

Switch from Carbimazole to Propylthiouracil immediately

Answer

Reassure and prescribe oral Paracetamol only

uk-plab-1 MCQ (SBA): Carbimazole-induced agranulocytosis

A 32-year-old woman with Graves’ disease has been on Carbimazole for 18 months. She presents with sore throat and fever. Her neutrophil count is 0.2 × 10^9/L. What is the most appropriate next step in management?