A 35-year-old man attends clinic with long-standing rheumatoid arthritis. He is on Methotrexate and Hydroxychloroquine. His CRP and DAS28 scores indic...

Question

A 35-year-old man attends clinic with long-standing rheumatoid arthritis. He is on Methotrexate and Hydroxychloroquine. His CRP and DAS28 scores indicate active disease despite adherence. What is the most appropriate next step in management?

Accepted Answer

Add a biological DMARD in consultation with rheumatology

Answer

Increase Methotrexate dose above recommended maximum

Answer

Start long-term high-dose oral Prednisolone alone

Answer

Stop Methotrexate and use NSAIDs only

Answer

Switch Hydroxychloroquine to Paracetamol

uk-plab-1 MCQ (SBA): Rheumatoid arthritis escalation

A 35-year-old man attends clinic with long-standing rheumatoid arthritis. He is on Methotrexate and Hydroxychloroquine. His CRP and DAS28 scores indicate active disease despite adherence. What is the most appropriate next step in management?