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ModerateCardiovascularPrimary hypertensionuk-plab-1

A 45-year-old white British man is found to have a clinic blood pressure of 162/96 mmHg on repeated measurements. Ambulatory monitoring confirms an average daytime blood pressure of 154/94 mmHg. He has no diabetes, no target organ damage and a 10-year QRISK score of 12%. What is the most appropriate first-line antihypertensive drug?

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