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EasyRespiratoryAcute severe asthma (adult)uk-plab-1

A 26-year-old man with a history of asthma presents with worsening wheeze and breathlessness over the last 6 hours. He is speaking in short phrases, respiratory rate is 32 breaths/min, pulse 120 bpm, oxygen saturation 92% on air, and peak expiratory flow is 45% of his best. There are widespread wheezes on auscultation. What is the most appropriate initial management?

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