A 47 year old woman presents with fatigue, glossitis and paraesthesia in her hands and feet. Full blood count shows macrocytic anaemia and blood film ...

Question

A 47 year old woman presents with fatigue, glossitis and paraesthesia in her hands and feet. Full blood count shows macrocytic anaemia and blood film suggests megaloblastic changes. Intrinsic factor antibodies are positive. According to BNF and NICE, what is the appropriate route of vitamin B12 replacement in pernicious anaemia?

Accepted Answer

Intramuscular Hydroxocobalamin

Answer

Oral Cyanocobalamin only

Answer

Intravenous Cyanocobalamin infusion

Answer

Transdermal B12 patches

Answer

No replacement is needed if diet is adequate

uk-plab-1 MCQ (SBA): Pernicious anaemia