A 58-year-old man presents to the emergency department with a 45-minute history of central crushing chest pain radiating to his left arm. He is clammy and nauseated. His ECG shows ST elevation in leads II, III and aVF. He arrived 40 minutes after symptom onset and is 20 minutes from a primary PCI centre. There are no contraindications to reperfusion. What is the most appropriate next step in his acute management?