A 34-year-old woman presents with iron-deficiency anaemia and intermittent diarrhoea, bloating and weight loss. Blood tests show raised tissue transgl...

Question

A 34-year-old woman presents with iron-deficiency anaemia and intermittent diarrhoea, bloating and weight loss. Blood tests show raised tissue transglutaminase IgA antibodies. What is the most appropriate next step to confirm the diagnosis?

Accepted Answer

Duodenal biopsy while continuing a gluten-containing diet

Answer

Start a strict gluten-free diet immediately and review in 6 months

Answer

Small bowel barium follow-through

Answer

HLA typing for DQ2 and DQ8

Answer

Colonoscopy with random colonic biopsies

uk-plab-1 MCQ (SBA): Coeliac disease

A 34-year-old woman presents with iron-deficiency anaemia and intermittent diarrhoea, bloating and weight loss. Blood tests show raised tissue transglutaminase IgA antibodies. What is the most appropriate next step to confirm the diagnosis?