Question

A 45-year-old woman presents with chronic diarrhoea, weight loss and iron deficiency anaemia. She reports bloating and intermittent abdominal pain. Examination shows no perianal disease. You suspect coeliac disease. What is the most appropriate initial investigation?

Accepted Answer

Tissue transglutaminase IgA antibody with total IgA level

Answer

Small bowel barium follow-through

Answer

Colonoscopy with random biopsies

Answer

HLA typing for DQ2 and DQ8

Answer

Capsule endoscopy

Practice question

A 45-year-old woman presents with chronic diarrhoea, weight loss and iron deficiency anaemia. She reports bloating and intermittent abdominal pain. Examination shows no perianal disease. You suspect coeliac disease. What is the most appropriate initial investigation?