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ModerateRespiratoryChronic obstructive pulmonary diseaseuk-plab-1

A 65-year-old ex-smoker with COPD reports daily breathlessness on exertion despite using a short-acting bronchodilator inhaler as required. Spirometry shows FEV1 45% predicted. He has one moderate exacerbation per year. What is the most appropriate next step in inhaled maintenance therapy?

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