EasyPsychiatryModerate major depressive disorderuk-plab-1
A 45-year-old woman presents with low mood, anhedonia, fatigue and poor sleep for 3 months. She has no history of mania, psychosis or substance misuse. Symptoms cause moderate functional impairment and she has no active suicidal plan. She has tried basic sleep hygiene and self-help without benefit. According to NICE, what is an appropriate first-line treatment option?