A 52-year-old woman with primary hypothyroidism is stable on Levothyroxine 100 micrograms once daily. Recent TFTs show TSH 7.8 mU per litre (elevated)...

Question

A 52-year-old woman with primary hypothyroidism is stable on Levothyroxine 100 micrograms once daily. Recent TFTs show TSH 7.8 mU per litre (elevated) and free T4 at the lower end of normal. She feels tired but has no other new symptoms. What is the most appropriate adjustment to her therapy?

Accepted Answer

Increase Levothyroxine to 125 micrograms once daily

Answer

Reduce Levothyroxine to 75 micrograms once daily

Answer

Stop Levothyroxine for 4 weeks then restart at a lower dose

Answer

Add Liothyronine to her current Levothyroxine dose

Answer

Make no change; this represents optimal control

uk-plab-1 MCQ (SBA): Primary hypothyroidism replacement

A 52-year-old woman with primary hypothyroidism is stable on Levothyroxine 100 micrograms once daily. Recent TFTs show TSH 7.8 mU per litre (elevated) and free T4 at the lower end of normal. She feels tired but has no other new symptoms. What is the most appropriate adjustment to her therapy?