A 48-year-old woman presents with painful, swollen metacarpophalangeal joints and prolonged early morning stiffness for 90 minutes. Examination shows ...

Question

A 48-year-old woman presents with painful, swollen metacarpophalangeal joints and prolonged early morning stiffness for 90 minutes. Examination shows symmetrical synovitis of the small joints of the hands. What is the most appropriate initial disease-modifying treatment once the diagnosis is confirmed?

Accepted Answer

Methotrexate as monotherapy with appropriate monitoring

Answer

Paracetamol alone

Answer

Non-steroidal anti-inflammatory drugs only

Answer

Oral Prednisolone long-term as monotherapy

Answer

Hydroxychloroquine alone for all cases

uk-plab-1 MCQ (SBA): Rheumatoid arthritis