Question

A 35-year-old woman with newly diagnosed rheumatoid arthritis has high disease activity despite NSAIDs. According to modern RA treatment principles, what is the recommended first-line disease-modifying agent?

Accepted Answer

Methotrexate monotherapy with folic acid supplementation

Answer

Hydroxychloroquine monotherapy

Answer

Sulfasalazine monotherapy

Answer

Long-term oral corticosteroids alone

Answer

Biologic agent as first-line without conventional DMARDs

Practice question

A 35-year-old woman with newly diagnosed rheumatoid arthritis has high disease activity despite NSAIDs. According to modern RA treatment principles, what is the recommended first-line disease-modifying agent?