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MediumPsychiatryMajor depressive disorderca-mccqe1ca-ccfpca-rcpsc-im

A 35-year-old woman presents with low mood, anhedonia, poor sleep and low energy for 6 weeks. There are no psychotic features, substance misuse or significant suicide risk, and she has no prior depression. According to CANMAT 2023 guidelines, what is an appropriate first-line treatment option?

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