A 45-year-old woman presents with a 2-hour history of unilateral facial droop and difficulty speaking. On arrival her blood pressure is 180/95 mm Hg, and glucose is 6.5 mmol/L. Neurological examination confirms expressive aphasia and right facial weakness; NIHSS score is 6. Symptoms began 90 minutes ago. According to Canadian Stroke Best Practice Recommendations, what is the most appropriate next step?