Question

A 68-year-old woman with CKD and thiazide use presents with confusion and a serum sodium of 112 mmol/L, gradually worsening over 4 days. She is haemodynamically stable without seizures. What is the safest recommended maximum correction rate of serum sodium in 24 hours to minimise risk of osmotic demyelination?

Accepted Answer

10-12 mmol/L in 24 hours, generally aiming for ≤8 mmol/L

Answer

>20 mmol/L in 24 hours

Answer

15-20 mmol/L in 24 hours

Answer

5 mmol/L in 24 hours, never exceeding 6 mmol/L

Answer

No limit is required if the patient is symptomatic

Practice question