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EasyRespiratoryAcute asthma management in adultsau-amcau-acem

A 45-year-old man with known asthma presents to the emergency department with increasing shortness of breath and wheeze over 3 hours. He is speaking in phrases, respiratory rate is 26 breaths/min, oxygen saturation 92% on room air, pulse 110 beats/min and peak expiratory flow is 55% of predicted. There is widespread wheeze on auscultation. What is the most appropriate initial management?

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