Question

A 35-year-old man presents with fatigue and dyspnoea. Full blood count shows Hb 85 g/L, MCV 68 fL, low ferritin and elevated total iron-binding capacity. Which of the following is the most appropriate initial investigation to identify the underlying cause?

Accepted Answer

Colonoscopy

Answer

Serum vitamin B12 and folate levels

Answer

Bone marrow biopsy

Answer

Genetic testing for thalassaemia

Answer

Coagulation profile

Practice question

A 35-year-old man presents with fatigue and dyspnoea. Full blood count shows Hb 85 g/L, MCV 68 fL, low ferritin and elevated total iron-binding capacity. Which of the following is the most appropriate initial investigation to identify the underlying cause?