A 42-year-old woman on sertraline and tramadol develops agitation, tremor, hyperreflexia, clonus and hyperthermia after dose increases. What is the mo...

Question

A 42-year-old woman on sertraline and tramadol develops agitation, tremor, hyperreflexia, clonus and hyperthermia after dose increases. What is the most appropriate immediate management?

Accepted Answer

Cease serotonergic drugs and provide supportive care with benzodiazepines and cooling

Answer

Increase sertraline dose

Answer

Administer haloperidol and continue medications

Answer

Give flumazenil

Answer

Advise no change and review in a week

au-acem MCQ (SBA): Serotonin syndrome management

A 42-year-old woman on sertraline and tramadol develops agitation, tremor, hyperreflexia, clonus and hyperthermia after dose increases. What is the most appropriate immediate management?