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MediumPsychiatryMajor depressive disorder first-line treatmentca-mccqe1ca-ccfp

A 46-year-old woman presents with low mood, anhedonia, early morning waking and reduced appetite for 6 weeks, causing impairment at work. She has no psychotic or bipolar features and no suicidality. According to CANMAT 2023 guidelines, what is the most appropriate first-line treatment approach?

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